MOLECULAR DESIGN OF NOVEL PGI(2) AGONISTS WITHOUT PG SKELETON .2.

Authors
HAMANAKA N TAKAHASHI K NAGAO Y TORISU K TAKADA H TOKUMOTO H KONDO K
Citation
N. Hamanaka et al., MOLECULAR DESIGN OF NOVEL PGI(2) AGONISTS WITHOUT PG SKELETON .2., Bioorganic & medicinal chemistry letters, 5(10), 1995, pp. 1071-1076
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
10
Year of publication
1995
Pages
1071 - 1076
Database
ISI
SICI code
0960-894X(1995)5:10<1071:MDONPA>2.0.ZU;2-N
Abstract
Introduction of alkyl groups at the oximium carbon of the PGI(2) agoni sts 3a and 4a has led to a series of potent PGI(2) mimetics. The most effective compounds are 3c and 3d, whose agonistic activity for human platelet PGI(2) receptors is almost the same as that of PGE(1).