MOLECULAR DESIGN OF NOVEL PGI(2) AGONISTS WITHOUT PG SKELETON .3.

Authors
HAMANAKA N TAKAHASHI K NAGAO Y TORISU K TOKUMOTO H KONDO K
Citation
N. Hamanaka et al., MOLECULAR DESIGN OF NOVEL PGI(2) AGONISTS WITHOUT PG SKELETON .3., Bioorganic & medicinal chemistry letters, 5(10), 1995, pp. 1077-1082
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
10
Year of publication
1995
Pages
1077 - 1082
Database
ISI
SICI code
0960-894X(1995)5:10<1077:MDONPA>2.0.ZU;2-H
Abstract
Several ether, oxime, and amide derivatives related to 1 and 3 were sy nthesized and tested as PGI(2) agonists. The results reveal the import ance of the orientation between carboxylic acid and terminal diphenyl groups in order to obtain high affinity interaction with PGI(2) recept ors.