MOLECULAR DESIGN OF NOVEL PGI(2) AGONISTS WITHOUT PG SKELETON .4.

Authors
HAMANAKA N TAKAHASHI K NAGAO Y TORISU K TOKUMOTO H KONDO K
Citation
N. Hamanaka et al., MOLECULAR DESIGN OF NOVEL PGI(2) AGONISTS WITHOUT PG SKELETON .4., Bioorganic & medicinal chemistry letters, 5(10), 1995, pp. 1083-1086
Citations number
2
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
10
Year of publication
1995
Pages
1083 - 1086
Database
ISI
SICI code
0960-894X(1995)5:10<1083:MDONPA>2.0.ZU;2-I
Abstract
The synthesis and biological evaluation of a novel series of di or tet rahydronaphthalene-5-oxyacetic acid derivatives with the 4-benzhydryl pyrazole group is described. Among these compounds, 7 has been identif ied as a highly potent PGI(2) agonist with an exceptionally long in vi vo duration of action.