SYNTHESIS AND BIOACTIVITIES OF HETEROCYCLIC LIPIDS AS PAF ANTAGONISTS.2.

Authors
CHUNG SK BAN SH KIM SH KIM BE WOO SH
Citation
Sk. Chung et al., SYNTHESIS AND BIOACTIVITIES OF HETEROCYCLIC LIPIDS AS PAF ANTAGONISTS.2., Bioorganic & medicinal chemistry letters, 5(10), 1995, pp. 1097-1102
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
10
Year of publication
1995
Pages
1097 - 1102
Database
ISI
SICI code
0960-894X(1995)5:10<1097:SABOHL>2.0.ZU;2-#
Abstract
Conformationally constrained analogues of platelet activating factor i ncorporating a lipophile and a pyridine-like heterocycle linked to cor e groups such as 1,1-bis(hydroxymethyl)cyclobutane and 2,4-bis(hydroxy methyl)-oxetane, -thietane and -azetidine skeletons via hydrogen bond acceptors such as ether and/or carbamate have been synthesized, and th eir in vitro and in vivo bioactivitites have indicated potent and sele ctive PAF antagonism.