The second published case of amyloidoma in the pelvis and sacrum is re
ported. Fine needle aspiration biopsy revealed multinucleate giant cel
ls, lymphocytes and plasma cells, some atypical. Congo red staining of
the cell block and aspirate showed focal, apple-green birefringence c
onsistent with amyloid. The histologic, radiologic and clinical featur
es of this case are discussed, and the cytologic findings in previousl
y reported fine needle aspiration biopsies of amyloidomas are reviewed
.