SECRETORY CARCINOMA OF THE BREAST ASSOCIATED WITH JUVENILE PAPILLOMATOSIS IN A 12-YEAR-OLD GIRL - A CASE-REPORT

A rare case of juvenile secretory carcinoma (SC) associated with juven ile papillomatosis (JP) is described. Tumor biopsy and fine needle asp iration cytology (FNAC) were performed in a 12-year-old girl who had n oticed a painful right breast mass. One of the two types of tumor cell s found on FNAC smears formed mainly sheets or clusters, intracellular spaces within the sheets and intracytoplasmic vacuolation. These cell s, a few of which had a signet-ring cell appearance with completely di sordered and randomly arranged nuclei, were considered to be SC cells. Cells of the other type were found in scattered papillary clusters an d had well-defined cytoplasmic borders, uniform cell and nuclear size, and an orderly nuclear arrangement, suggesting It benign papillary le sion. Histologic examination of the tumor biopsy and breast quadrantec tomy specimens revealed SC with JP. The cytologic, histologic and elec tron microscopic features of SC are described, and the relationship be tween SC and JP is discussed.