Over the past ten years, a large amount of research has been done inve
stigating materials, both glasses and polymers, which exhibit large no
n-linear susceptibilities, chi(3). The measured chi(3) for a wide rang
e of inorganic glasses are presented and discussed in terms of chemica
l composition. The experimental results from a single mode fiber with
a large non-resonant chi(3) are presented. An argument is made for the
choice of the non-resonant non-linear effect in cylindrical optical w
aveguides as the most practical route toward the realization of device
s utilizing non-linear interactions. The argument takes into account v
arious aspects that influence device performance other than the magnit
ude of chi(3) alone. A brief discussion of the resonant non-linear phe
nomena derived from band-filling in semiconductor doped glasses and th
e photorefractive effect in SiO2-GeO2 waveguide materials is included
for comparison.