ANTITHROMBOTIC ACTIVITY OF A SYMMETRICAL TRIGLYCERIDE WITH EICOSAPENTAENOIC ACID AND GAMMA-LINOLENIC ACID IN GUINEA-PIG MESENTERIC MICROVASCULATURE

Authors
AKAHANE N OHBA S SUZUKI J WAKABAYASHI T NAKAHARA T YANAGI K OHSHIMA N
Citation
N. Akahane et al., ANTITHROMBOTIC ACTIVITY OF A SYMMETRICAL TRIGLYCERIDE WITH EICOSAPENTAENOIC ACID AND GAMMA-LINOLENIC ACID IN GUINEA-PIG MESENTERIC MICROVASCULATURE, Thrombosis research, 78(5), 1995, pp. 441-450
Citations number
36
Categorie Soggetti
Hematology,"Cardiac & Cardiovascular System","Peripheal Vascular Diseas
Journal title
Thrombosis research → ACNP
ISSN journal
00493848
Volume
78
Issue
5
Year of publication
1995
Pages
441 - 450
Database
ISI
SICI code
0049-3848(1995)78:5<441:AAOAST>2.0.ZU;2-I
Abstract
The antithrombotic effect of a synthetic symmetrical triglyceride havi ng eicosapentaenoic acid (EPA) at positions 1 and 3, and gamma-linolen ic acid (GL;1) at position 2 was investigated. Administration of the t riglyceride significantly increased thrombus formation time and thromb otic occlusion time induced by light irradiation and a fluorescent dye in guinea pigs after 14 days administration compared to that of soybe an oil. The antithrombotic effect of the triglyceride was similar to t hat of EPA ethyl eater. Administration of the triglyceride increased G LA, dihomo-gamma-linolenic acid (DGLA) and EPA contents in plasma and the liver, and the ratio of DGLA to arachidonic acid. These results mi ght be responsible for this antithrombotic effect.