ATTENUATION OF NEOSTRIATAL PREPROENKEPHALIN AND PREPROTACHYKININ MESSENGER-RNA ABUNDANCE BY CHRONIC TREATMENT WITH THE KAINATE QUISQUALATE RECEPTOR ANTAGONIST 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE IN THE RAT-BRAIN

Authors
VILLEGAS M ANGULO JA
Citation
M. Villegas et Ja. Angulo, ATTENUATION OF NEOSTRIATAL PREPROENKEPHALIN AND PREPROTACHYKININ MESSENGER-RNA ABUNDANCE BY CHRONIC TREATMENT WITH THE KAINATE QUISQUALATE RECEPTOR ANTAGONIST 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE IN THE RAT-BRAIN, Neuroscience letters, 191(1-2), 1995, pp. 51-54
Citations number
27
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
191
Issue
1-2
Year of publication
1995
Pages
51 - 54
Database
ISI
SICI code
0304-3940(1995)191:1-2<51:AONPAP>2.0.ZU;2-O
Abstract
The present investigation asses sed the effect of chronic blockade of kainate/quisqualate binding sites with 6-cyano-7-nitroquinoxaline-2,3- dione (CNQX) on preproenkephalin (PPE) and preprotachykinin (PPT) mRNA abundance in the neostriatum of the rat brain. Daily injection of CNQ X for seven consecutive days decreased PPE mRNA abundance approximatel y 25% below vehicle-injected controls in dorsolateral, dorsomedial, an terior caudate-putamen (dlCPu, dmCPu and aCPu, respectively) and nucle us accumbens (NAc). Similarly, PPT mRNA abundance was significantly de creased in dlCPu, dmCPu and aCPu but not in the accumbens. The data de monstrate that non-NMDA receptor activity modulates basal levels of ex pression of PPE and PPT mRNAs in the neostriatum of the rat brain.