ANALYSIS OF THE PHASE-SHIFTING EFFECTS OF GASTRIN-RELEASING PEPTIDE WHEN MICROINJECTED INTO THE SUPRACHIASMATIC REGION

Authors
ALBERS HE GILLESPIE CF BABAGBEMI TO HUHMAN KL
Citation
He. Albers et al., ANALYSIS OF THE PHASE-SHIFTING EFFECTS OF GASTRIN-RELEASING PEPTIDE WHEN MICROINJECTED INTO THE SUPRACHIASMATIC REGION, Neuroscience letters, 191(1-2), 1995, pp. 63-66
Citations number
21
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
191
Issue
1-2
Year of publication
1995
Pages
63 - 66
Database
ISI
SICI code
0304-3940(1995)191:1-2<63:AOTPEO>2.0.ZU;2-C
Abstract
The role of gastrin releasing peptide (GRP) in phase shifting circadia n rhythms was investigated. Microinjection of GRP into the suprachiasm atic region (SCN) region produced only small changes in the phase of f ree-running circadian activity rhythms in hamsters housed in constant darkness. However, co-administration of GRP with vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) produced signifi cantly larger phase delays than GRP alone. These data support the hypo thesis that GRP interacts with VIP and PHI within the SCN to induce ph ase shifts of circadian rhythms.