SPONTANEOUS EXCITATORY POSTSYNAPTIC CURRENTS IN HIPPOCAMPAL CA1 PYRAMIDAL NEURONS OF THE GERBIL AFTER TRANSIENT ISCHEMIA

The changes in the spontaneous excitatory postsynaptic currents (sEPSC s) after transient cerebral ischemia were studied using whole-cell rec ording from CA1 pyramidal neurons in the gerbil. In neurons recorded 1 -2 days after ischemia, sEPSCs had a slowed time course with the decay time constant fitted by a single exponential and it progressively inc reased after ischemia. Frequency and amplitude distribution of sEPSCs in ischemic neurons were not significantly different from those in the control neurons. The results support the view that abnormal non-N-met hyl-D-aspartic acid currents originate at the degenerated postsynaptic site, unrelated to the presynaptic releasing mechanisms.