L. Sanchezramos et al., CALCIUM SUPPLEMENTATION IN MILD PREECLAMPSIA REMOTE FROM TERM - A RANDOMIZED DOUBLE-BLIND CLINICAL-TRIAL, Obstetrics and gynecology, 85(6), 1995, pp. 915-918
Objective: To determine whether calcium supplementation prevents progr
ession to severe disease in preterm nulliparous women with mild preecl
ampsia. Methods: Seventy-five women hospitalized at 24-36 weeks' gesta
tion because of mild preeclampsia were randomized to receive either 2
g/day of elemental calcium (36 women) or placebo (39). Both groups had
similar demographic characteristics, initial blood pressure measureme
nts, and amount of proteinuria. Diagnostic criteria and clinical manag
ement for severe preeclampsia were applied consistently. Results: Eigh
teen of 36 calcium-treated subjects (50%, 95% confidence interval [CI]
33-67) developed severe preeclampsia, compared with 19 of 39 (48.7%,
95% CI 32-65) in the placebo group (relative risk 1.03, 95% CI 0.64-1.
03; P = 1.00). Blood pressure values, gestational age at delivery, new
born weights, incidence of low Apgar scores, and umbilical arterial bl
ood gases were similar for the two groups. Conclusion: Calcium supplem
entation does not prevent severe preeclampsia in preterm patients with
mild disease.