Km. Sivanandaiah et al., IODOTRICHLOROSILANE AS N-ALPHA-Z CLEAVING AGENT IN SOLID-PHASE SYNTHESIS OF DERMORPHIN AND OXYTOCIN, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 34(6), 1995, pp. 487-491
Iodotrichlorosilane, prepared by mixing freshly distilled silicon tetr
achloride and sodium or potassium iodide, can be used for the efficien
t cleavage of N-alpha-benzyloxycarbonyl group in stepwise solid phase
peptide synthesis. Thus, the opioid heptapeptide, dermorphin and the p
ituitary hormone, oxytocin have been synthesized in good yield and pur
ity.