ACUTE MYELOID-LEUKEMIA AND DIABETES-INSIPIDUS - RESULTS IN 5 PATIENTS

Authors
CASTAGNOLA C MORRA E BERNASCONI P ASTORI C SANTAGOSTINO A BERNASCONI C
Citation
C. Castagnola et al., ACUTE MYELOID-LEUKEMIA AND DIABETES-INSIPIDUS - RESULTS IN 5 PATIENTS, Acta haematologica, 93(1), 1995, pp. 1-4
Citations number
14
Categorie Soggetti
Hematology
Journal title
Acta haematologica → ACNP
ISSN journal
00015792
Volume
93
Issue
1
Year of publication
1995
Pages
1 - 4
Database
ISI
SICI code
0001-5792(1995)93:1<1:AMAD-R>2.0.ZU;2-I
Abstract
The clinical and hematological characteristics of 5 patients affected with both acute myeloid leukemia (AML) and diabetes insipidus (DI) are described. Banded chromosomal analysis demonstrated monosomy 7 in 2 p atients and a complex cytogenetic rearrangement in another. No patient entered complete remission with standard induction chemotherapy. Thes e data confirm that in patients with AML, the association of DI (with or without monosomy 7) is an unfavorable prognostic factor.