THE HOST TISSUE REACTION TO MADURELLA-MYCETOMATIS - NEW CLASSIFICATION

In this prospective study, three types of tissue reaction to mycetoma grains are described. Type I reaction is characterized by the adherenc e of neutrophils to the surface of the grain leading to its disintegra tion. In Type II reaction, the fragmented grain and the dead neutrophi ls are cleared by macrophages and multinucleated giant cells, while in Type III reaction there is a discrete well developed epithelioid gran uloma with Langhans's giant cells. The three types of reaction are usu ally seen in different combinations in the same lesion.