A series of 18 patients with unexpected well-differentiated cancers of
the thyroid is presented. This proved to be a high percentage of all
patients operated for ''benign'' thyroid disease (6,5%), and a substan
tial percentage of all patients operated for thyroid cancer (44%). Pre
operative investigations consisting mainly of thyroid function tests,
ultrasound, scintigraphy, and fine needle aspiration biopsy, were not
contributive for cancer. Intraoperative suspicion of malignancy induce
d extended surgery in one patient and frozen section biopsies in anoth
er 5 patients, with 3 positive answers resulting in immediate more rad
ical operations. In 12 patients unsuspected cancer was diagnosed at pa
raffin section. This resulted in reoperation in 8 patients. Considerin
g a number of arguments, we advocate a therapeutical guideline which m
akes a distinction between tumours which should be reoperated and tumo
urs which are adequately treated by the initial resection.