O. Hotta et al., MESANGIOLYSIS ASSOCIATED WITH SEVERE GLOMERULAR ENDOCAPILLARY PROLIFERATION OF CD57 LARGE GRANULAR LYMPHOCYTES, Clinical nephrology, 43(5), 1995, pp. 297-302
A 54-year-old man developed renal failure, with renal biopsy findings
of diffuse mesangiolysis with severe endocapillary proliferation. Immu
nohistochemical studies revealed that CD3(-)CD56(-)CD57(+) large granu
lar lymphocytes were present predominantly within glomerular tufts. In
tercellular adhesion molecule-1 was more preferentially expressed in t
he glomerular endothelial cells with severe endocapillary proliferatio
n as compared to those without endocapillary proliferation. These find
ings suggest that CD57(+) large granular lymphocytes caused glomerular
endothelial injury by a cell-mediated cytolytic mechanism, resulting
in the development of mesangiolysis and microaneurysm formation.