THE EFFECTIVENESS OF LOW-MOLECULAR-WEIGHT HEPARIN ON ADHESION FORMATION IN EXPERIMENTAL RAT MODEL

In our experimental animal model, 50 Winstar-Albino rats were divided into five groups in a randomized manner. After all were anesthesized w ith ether, laparotomy was performed on each one and the caecum and ter minal ileum were scrubbed with a toothbrush until serosal petechial bl eedings were seen. In the first group, the abdomen was closed after th is procedure. In the second group, the abdomen was closed after applic ation of 0.9% NaCl solution intraperitoneally. In the third group, the abdomen was closed after LMWH (low molecular weight heparin) was give n intraperitoneally. In the fourth group, LMWH was given in prophylact ic dosage subcutaneously on the day of operation and for the following seven days. In the fifth group, abdomen was closed after heparin was given intraperitoneally. On the fourteenth postoperative day, the rats were sacrificed and intraperitoneal adhesions were scored according t o the ''Mazuji's Scale''. There was a statistically significant differ ence between group I and group III. No statistically significant diffe rence could be found between group I and group IV (p>0.05). Between gr oup I and V a statistically significant difference was found (p<0.005) . Again a statistically significant difference was found both between group III and IV (p<0.05), and between group IV and V (p<0.001). No su ch difference was observed between group IV and V (p>0.05). As a resul t, in this animal model, LMWH given intraperitoneally to prevent adhes ions was found to be more effective than subcutaneous and intraperiton eal heparin application.