DBI MESSENGER-RNA IS EXPRESSED IN ENDOCRINE PANCREAS AND ITS POSTTRANSLATIONAL PRODUCT DBI33-50 INHIBITS INSULIN RELEASE

Authors
BORBONI P MAGNATERRA R PORZIO O FUSCO A SESTI G BERTOLI A LAURO R MARLIER LNJL
Citation
P. Borboni et al., DBI MESSENGER-RNA IS EXPRESSED IN ENDOCRINE PANCREAS AND ITS POSTTRANSLATIONAL PRODUCT DBI33-50 INHIBITS INSULIN RELEASE, Endocrine, 3(4), 1995, pp. 267-271
Citations number
43
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Endocrine → ACNP
ISSN journal
1355008X
Volume
3
Issue
4
Year of publication
1995
Pages
267 - 271
Database
ISI
SICI code
1355-008X(1995)3:4<267:DMIEIE>2.0.ZU;2-R
Abstract
It has been previously demonstrated that DBI is present in endocrine p ancreas and it is able to inhibit insulin release in isolated rat isle ts. Its mechanism of action has been investigated, demonstrating the p ossible involvement of cAMP and ATP-dependent K+ channels. DBI33-50, a post-translational product of DBI, is also able to inhibit insulin re lease, but its action has not been characterized. In the present study , we have investigated the presence of DBI mRNA in pancreas, islets an d cultured beta cells. The possible mechanism of action of DBI33-50 an d the involvement of BZ/GABA(A) receptors has been studied.