IMMUNOHISTOCHEMICAL STUDY OF MAMMARY AND EXTRAMAMMARY PAGETS-DISEASE

Immunophenotypes of mammary (MPD) and extra-mammary Paget's disease (E PD) are still not well understood. Thirty-four formalin-fixed paraffin -embedded tissue sections from 33 patients with 6 MPD and 28 EPD were studied immunohistochemically with the use of polyclonal c-erbB-2 and pS2 antisera, and monoclonal nm23, B6.2, GCDFP-15, and p53 antibodies. Cases of MPD expressed a high incidence of c-erbB-2 and nm23 compared with those of EPD (100% vs. 29% p<0.01, and 83% vs. 29%; p<0.05, resp ectively). Although high expression of B6.2 (>83%) and moderate expres sion of GCDFP-15 (33-39%), pS2 (33-46%) and p53 (39-50%) were seen, th e positivity was not significantly different between MPD and EPD. Thes e findings indicate that MPD and EPD share immunohistochemical feature s but partially differ in their patterns of antigen expression.