RESULTS OF THE PRIMARY-TREATMENT IN T1-3MO PROSTATIC ADENOCARCINOMA ARE DEPENDENT ON TUMOR BIOLOGY

The results of the primary treatment were analysed in relation to biol ogical prognostic factors in a series of 215 males with T1-3MO prostat ic adenocarcinoma. T-category, Gleason score and DNA ploidy were signi ficantly related to progressive-free survival and overall survival. In cidental tumours usually had a favorable prognosis, 86% of them being diploid, whereas the incidental aneuploid tumours (14%) ran an unfavor able course. In clinically malignant prostates (TPR), neither Gleason score nor DNA ploidy had prognostic significance. The treatment had pr ognostic significance only in diploid tumours or in tumours with Gleas on score value less than or equal to 17, while aneuploid tumours or tu mours with Gleason score value >7 always had unfavorable prognosis irr espective of treatment. Tumours treated by radical prostatectomy or by radical radiation treatment were associated with a favorable prognosi s, as contrasted to the tumours treated by endocrine treatment or thos e followed-up only, which had a high rate of mortality. Transurethral resection was wekly related to increased risk of death from prostatic adenocarcinoma, although the basic mechanisms behind this observation remain to be explained.