E. Carico et al., CA-125 IN OVARIAN CYSTS, SEROUS EFFUSIONS AND PERITONEAL WASHINGS - IMMUNOCYTOCHEMICAL EXPRESSION, Anticancer research, 15(2), 1995, pp. 631-634
The immunocytochemical expression of CA 125 in ovarian cysts, serous e
ffusions and peritoneal washings was examined in patients with primary
ovarian malignancies (22) and benign gynecologic conditions (96). The
immunostaining of CA 125 was assessed in serous ovarian cysts (CA 125
was detected in 3 out of 14 serous ovarian cysts), follicular ovarian
cysts (0/5), luteinized cysts (3/3), endometriotic cysts (6/11), sero
us cystoadenomas (4/4) and mucinous cystoadenomas (0/2). Reactive meso
thelial cells (6/6) showed a low but homogeneous staining which was ne
ver found in negative peritoneal washings (0/47). Neoplastic cells in
positive peritoneal washings were highly positive (20/22), except for
2 mucinous cystoadenocarcinomas. The reactivity of OC 125 with endomet
rial and reactive mesothelial cells shows the importance of employing
a combination of MoAbs to improve conventional morphologic diagnosis.