STRUCTURE-ACTIVITY STUDY ON ANTIULCER AGENTS USING WIENERS TOPOLOGICAL INDEX AND MOLECULAR CONNECTIVITY INDEX

The relationship of Wiener's topological index and molecular connectiv ity index with antiulcer activity of a series of 4-substituted-2-guani dino thiazole analogs has been investigated. The values of Wiener's to pological index and molecular connectivity index of 128 compounds were computed and active ranges were identified. The activity assigned to each analog using these topological descriptors was subsequently compa red with the reported in vitro and in vivo activities against gastric hydrogen-potassium stimulated adenosine triphosphatase (H+K+-ATPase) e nzyme. Predictions with an accuracy of the order of similar to 89% wer e observed with regard to in vivo activity using these topological ind ices.