STRUCTURE-ACTIVITY STUDY ON ANTIINFLAMMATORY PYRAZOLE CARBOXYLIC-ACIDHYDRAZIDE ANALOGS USING MOLECULAR CONNECTIVITY INDEXES

Authors
GOEL A MADAN AK
Citation
A. Goel et Ak. Madan, STRUCTURE-ACTIVITY STUDY ON ANTIINFLAMMATORY PYRAZOLE CARBOXYLIC-ACIDHYDRAZIDE ANALOGS USING MOLECULAR CONNECTIVITY INDEXES, Journal of chemical information and computer sciences, 35(3), 1995, pp. 510-514
Citations number
30
Categorie Soggetti
Information Science & Library Science","Computer Application, Chemistry & Engineering","Computer Science Interdisciplinary Applications",Chemistry,"Computer Science Information Systems
Journal title
Journal of chemical information and computer sciences → ACNP
ISSN journal
00952338
Volume
35
Issue
3
Year of publication
1995
Pages
510 - 514
Database
ISI
SICI code
0095-2338(1995)35:3<510:SSOAPC>2.0.ZU;2-7
Abstract
The relationship between molecular connectivity indices and the antiin flammatory activity of a series of pyrazole carboxylic acid hydrazide analogs has been investigated. The values of molecular connectivity in dex, valence molecular connectivity index, and a modified index, terme d as atomic molecular connectivity index for 76 compounds, were comput ed and active ranges were identified. Each compound was assigned an ac tivity which was subsequently compared with the reported activity agai nst lipoxygenase enzyme. Predictions with a degree of accuracy above 8 0% were observed using the valence molecular connectivity index.