Sd. Morley et al., ADRENAL-SPECIFIC TRANSGENE EXPRESSION AND DERIVATION OF CONDITIONALLYIMMORTAL RAT ADRENOCORTICAL CELL-LINES, Endocrine research, 21(1-2), 1995, pp. 353-357
Conditional immortalisation of cells is a powerful tool for establishi
ng in vitro models maintaining a differentiated phenotype. We are util
ising this approach to derive cell lines that maintain the characteris
tics of glomerulosa and fasciculata cells of the adrenal cortex. Such
cell lines should provide a system in which to study aspects of adreno
cortical function that are relevant to hypertension, such as the effec
ts of the renin-angiotensin system on steroidogenesis.