CORTISOL - A TOOL TO STUDY ALDOSTERONE BIOSYNTHESIS IN RATS

Authors
MATKOVIC L GOMEZSANCHEZ CE LANTOS CP COZZA EN
Citation
L. Matkovic et al., CORTISOL - A TOOL TO STUDY ALDOSTERONE BIOSYNTHESIS IN RATS, Endocrine research, 21(1-2), 1995, pp. 471-475
Citations number
8
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Endocrine research → ACNP
ISSN journal
07435800
Volume
21
Issue
1-2
Year of publication
1995
Pages
471 - 475
Database
ISI
SICI code
0743-5800(1995)21:1-2<471:C-ATTS>2.0.ZU;2-0
Abstract
Corticosterone (B) and 18-hydroxy-11-deoxycorticosterone (18OHDOC) but not 11-deoxycorticosterone (DOC) displaced cortisol (F) specifically bound to rat adrenal mitochondria. F competitively inhibited aldostero ne formation from B, 18OHB and 18OHDOC but did not inhibit conversions of DOC to B or 18OHDOC. High concentrations of DOC increased its conv ersion to 18OHDOC rather than B.