RECOGNITION ABILITY AND CYTOTOXICITY OF SOME OLIGOSACCHARIDYL SUBSTITUTED BETA-CYCLODEXTRINS

Citation
F. Attioui et al., RECOGNITION ABILITY AND CYTOTOXICITY OF SOME OLIGOSACCHARIDYL SUBSTITUTED BETA-CYCLODEXTRINS, Biology of the cell, 82(2-3), 1994, pp. 161-167
Citations number
19
Categorie Soggetti
Cell Biology
Journal title
ISSN journal
02484900
Volume
82
Issue
2-3
Year of publication
1994
Pages
161 - 167
Database
ISI
SICI code
0248-4900(1994)82:2-3<161:RAACOS>2.0.ZU;2-Z
Abstract
This paper reports a chemico-enzymatic synthesis of beta-CD derivative s. The recognition properties of these derivatives were tested using f locculating yeast and isolated lectins. It was observed that the subst itution of beta-cyclodextrins with galactose end arms induces the bett er recognition by a cell-linked galactose-specific lectin. The physico chemical effects of the beta-CD derivatives on membranes were estimate d using red blood cells and the effects on the viability of yeast and human rectal tumor cells were appreciated by measuring the mitochondri al deshydrogenase activity. The substitutions of the beta-CD ring by s ugar antennae decrease the negative physicochemical effects of the bet a-CD, ie their hemolytic properties. However, these substitutions indu ce significant modifications of the biological properties of the molec ules, particularly the cytotoxicity and the growth of eukaryotic cells .