F. Attioui et al., RECOGNITION ABILITY AND CYTOTOXICITY OF SOME OLIGOSACCHARIDYL SUBSTITUTED BETA-CYCLODEXTRINS, Biology of the cell, 82(2-3), 1994, pp. 161-167
This paper reports a chemico-enzymatic synthesis of beta-CD derivative
s. The recognition properties of these derivatives were tested using f
locculating yeast and isolated lectins. It was observed that the subst
itution of beta-cyclodextrins with galactose end arms induces the bett
er recognition by a cell-linked galactose-specific lectin. The physico
chemical effects of the beta-CD derivatives on membranes were estimate
d using red blood cells and the effects on the viability of yeast and
human rectal tumor cells were appreciated by measuring the mitochondri
al deshydrogenase activity. The substitutions of the beta-CD ring by s
ugar antennae decrease the negative physicochemical effects of the bet
a-CD, ie their hemolytic properties. However, these substitutions indu
ce significant modifications of the biological properties of the molec
ules, particularly the cytotoxicity and the growth of eukaryotic cells
.