ANTIIDIOTYPE INDUCTION THERAPY - EVIDENCE FOR THE INDUCTION OF IMMUNE-RESPONSE THROUGH THE IDIOTYPE NETWORK IN PATIENTS WITH OVARIAN-CANCERAFTER ADMINISTRATION OF ANTI-CA125 MURINE MONOCLONAL-ANTIBODY B43.13

Authors
MADIYALAKAN R SYKES TR DHARAMPAUL S SYKES CJ BAUM RP HOR G NOUJAIM AA
Citation
R. Madiyalakan et al., ANTIIDIOTYPE INDUCTION THERAPY - EVIDENCE FOR THE INDUCTION OF IMMUNE-RESPONSE THROUGH THE IDIOTYPE NETWORK IN PATIENTS WITH OVARIAN-CANCERAFTER ADMINISTRATION OF ANTI-CA125 MURINE MONOCLONAL-ANTIBODY B43.13, Hybridoma, 14(2), 1995, pp. 199-203
Citations number
17
Categorie Soggetti
Immunology
Journal title
Hybridoma → ACNP
ISSN journal
0272457X
Volume
14
Issue
2
Year of publication
1995
Pages
199 - 203
Database
ISI
SICI code
0272-457X(1995)14:2<199:AIT-EF>2.0.ZU;2-O
Abstract
The immune status of ovarian cancer patients receiving anti-CA125 muri ne monoclonal antibody B43.13 was evaluated by measuring antiidiotypic antibodies (Ab(2)), antiantudiotypic antibodies (Ab(3)), antiisotypic human antimouse antibodies (HAMA), interferon-gamma, and CA125 levels in the serum, A specific assay was developed for the determination of Ab(2) antibodies using chimeric MAb B43.13. Of the 50 patients studie d, 26 had elevated levels of Ab(2). Eleven of these 26 patients also h ad high titer of antiantudiotypic (Ab(3)) antibodies, Eight of the 22 patients analyzed had increased interferon-gamma levels, A tentative c orrelation was found between survival of these patients' antiidiotype induction.