VALUE OF ABDOMINAL FAT ASPIRATION AND LAB IAL SALIVARY-GLAND BIOPSY FOR THE DIAGNOSIS OF AMYLOIDOSIS IN ELDERLY - A PROSPECTIVE-STUDY IN 100 PATIENTS

Citation
Jl. Dupond et al., VALUE OF ABDOMINAL FAT ASPIRATION AND LAB IAL SALIVARY-GLAND BIOPSY FOR THE DIAGNOSIS OF AMYLOIDOSIS IN ELDERLY - A PROSPECTIVE-STUDY IN 100 PATIENTS, La Revue de medecine interne, 16(5), 1995, pp. 314-317
Citations number
NO
Categorie Soggetti
Medicine, General & Internal
ISSN journal
02488663
Volume
16
Issue
5
Year of publication
1995
Pages
314 - 317
Database
ISI
SICI code
0248-8663(1995)16:5<314:VOAFAA>2.0.ZU;2-2
Abstract
Primary and secondary amyloidosis are not uncommun in aging dot the di agnosis is rarely made on account of the risk of bleeding in the site of biopsies and the difficulty to distinguish senile from systemic amy loidosis on the biopsy samples. We have studied the frequency of amylo id deposition in the abdominal fat aspirate (AFA), the labial salivary gland (LSG), the temporal arteries (four cases), bone marrow (two cas es), digestive tract (four cases) in 100 elderly patients (aged 80 or greater). AFA was positive in 15 percent of the patients and LSG in 5% ; both samples were positive in 48. Four cases of systemic amyloidosis were found (two of the AL and two of the the AA type). Sensitivity of AFA was 75%, specificity was 87% and the positive predictive value wa s 20%. The values were respectively 100%, 99%, 100% for LSG. In I I pa tients whose AFA biopsies samples were singly positive, amyloid deposi ts were found in temporal arteries in four of four cases. We conclude that AFA is too sensitive for the diagnosis of systemic amyloidosis in aging. The responsibility of senile amyloid deposition on AFA should require further investigations. LSG biopsies seem to be a more reliabl e test for the diagnosis of primary and secondary amyloidosis in elder ly.