PRODUCTION IN RABBITS OF HIGH-LEVELS OF ANTI-HIV-1 GP160 ANTIBODIES

Authors
RELYVELD E BIZZINI B
Citation
E. Relyveld et B. Bizzini, PRODUCTION IN RABBITS OF HIGH-LEVELS OF ANTI-HIV-1 GP160 ANTIBODIES, Cellular and molecular biology, 41(3), 1995, pp. 389-393
Citations number
26
Categorie Soggetti
Cell Biology",Biology
Journal title
Cellular and molecular biology → ACNP
ISSN journal
01455680
Volume
41
Issue
3
Year of publication
1995
Pages
389 - 393
Database
ISI
SICI code
0145-5680(1995)41:3<389:PIROHO>2.0.ZU;2-Y
Abstract
The production of anti-HIV-1 gp160 antibodies was obtained in rabbits given gp160 either in saline or adsorbed onto calcium phosphate. Immun ization with gp160 in saline induced the formation of antibodies direc ted to the p18 protein, whereas the gp160 adsorbed onto calcium phosph ate elicited antibodies recognizing the gp160, p55, p25 and p18 protei ns. Calcium phosphate was found to be a powerful adjuvant and it shoul d be used for potentiating candidate anti-HIV vaccines.