CONTRIBUTION OF ALPHA-INTERFERON (ALPHA-IFN) TO HIV-INDUCED IMMUNOSUPPRESSION

Citation
A. Lachgar et B. Bizzini, CONTRIBUTION OF ALPHA-INTERFERON (ALPHA-IFN) TO HIV-INDUCED IMMUNOSUPPRESSION, Cellular and molecular biology, 41(3), 1995, pp. 431-437
Citations number
19
Categorie Soggetti
Cell Biology",Biology
ISSN journal
01455680
Volume
41
Issue
3
Year of publication
1995
Pages
431 - 437
Database
ISI
SICI code
0145-5680(1995)41:3<431:COA(TH>2.0.ZU;2-4
Abstract
In the present investigation we have shown that PBLs taken from HIV-po sitive patients suppressed T-cell proliferation when cultured for at l east 12 days. When infected In vitro with HIV-1, these cells become su ppressive after 6 days. PBLs collected from seronegative individuals t urned out to be non-suppressive even after prolonged culturing. Howeve r, when infected in vitro with HIV they were found to be cytostatic al so after 6 days. This anti-immune activity, related to HIV infection, is mediated, at least in part, by alpha IFN, since about 50% of this H IV associated activity could be quenched by alpha IFN antibodies. We a lso showed that this T-cell cytostasis is associated with CD8(+) cells . In view of a possible use of suppressive cells for T-cell vaccinatio n, we verified that such cellular functions were abolished by aldehyde treatment.