DIRECTED SELECTIVITY - THE SYNTHETIC CHEMISTS CONTRIBUTION TO EFFICIENCY

Authors
WINTERFELDT E
Citation
E. Winterfeldt, DIRECTED SELECTIVITY - THE SYNTHETIC CHEMISTS CONTRIBUTION TO EFFICIENCY, South African Journal of Chemistry, 47(3-4), 1994, pp. 77-82
Citations number
14
Categorie Soggetti
Chemistry
Journal title
South African Journal of Chemistry → ACNP
ISSN journal
03794350
Volume
47
Issue
3-4
Year of publication
1994
Pages
77 - 82
Database
ISI
SICI code
0379-4350(1994)47:3-4<77:DS-TSC>2.0.ZU;2-J
Abstract
The importance of directed selectivity for constitutional Es well as c onfigurational flexibility in total synthesis is illustrated with a fe w examples from the author's own work. Factors such as thermodynamic V ersus kinetic control, active versus inactive space demand and changes in reaction mechanism are shown to exercise a significant influence o n chemoselectivity, regioselectivity and diastereoselectivity.