P. Subramaniam et al., HEPARIN-REBOUND IN THE EARLY POSTOPERATIVE PHASE FOLLOWING CARDIOPULMONARY BYPASS, Australian and New Zealand journal of surgery, 65(5), 1995, pp. 331-333
The incidence of the 'heparin-rebound' phenomenon after protamine neut
ralization of systemic heparinization required for cardiopulmonary byp
ass (CPB) was investigated. Heparin-effect was detected in 43% of pati
ents studied at 2 h, 31% at 4 h, and 37% at 8 h after reversal of circ
uit heparin on CPB. Heparin-rebound was shown to be associated with a
small but significant increase in postoperative bleeding which was not
of clinical importance.