Am. Khalil et al., PROLONGED INTAKE OF CHLORAMBUCIL FOR OVARIAN-CANCER, European journal of obstetrics, gynecology, and reproductive biology, 60(1), 1995, pp. 85-86
The use of alkylating agents has been reported to be a cause of second
ary leukemia particularly in patients surviving for 2 years or more af
ter treatment of ovarian carcinoma. The risk of developing leukemia is
possibly related to the duration of treatment and the total dose of a
lkylating agents administered. We report a patient with epithelial ova
rian carcinoma who received chlorambucil for 130 consecutive months wi
th no clinical or laboratory evidence of leukemia.