SEROTONERGIC MODULATION OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE (MDMA)-ELICITED REDUCTION OF RESPONSE RATE BUT NOT REWARDING THRESHOLD IN ACCUMBAL SELF-STIMULATION

In a fixed interval 5-s rate-frequency function paradigm with rats, 3, 4-methylenedioxymethamphetamine (MDMA; 0.5, 2 and 4 mg/kg) dose-depend ently decreased response rate for nucleus accumbens self-stimulation w hile both D-amphetamine (0.3 and 1 mg/kg) and cocaine (5 and 15 mg/kg) increased response rates. The highest dose of MDMA caused a cessation of responding in many of the rats tested, but in those rats that cont inued to respond a significant reduction in frequency threshold for se lf-stimulation was seen. Cocaine and amphetamine dose-dependently redu ced frequency threshold in all rats tested. The non-specific serotonin antagonist, methysergide (5 mg/kg), reversed the inhibitory effects o f MDMA on response rates and caused all rats to respond following MDMA (4 mg/kg). Methysergide did not affect MDMA's threshold-lowering prop erties and when administered alone methysergide had no effect on self- stimulation. These results suggest serotonergic involvement in the per formance but not reinforcement-modulating effect of MDMA in the self-s timulation paradigm.