IN-VITRO TEST SYSTEMS

Experimental in vitro systems are discussed with reference to their us e as models fur the analysis of basal tumor-host interactions. Multipl e functions of macrophages are treated and there is also a special foc us on the differentiation of macrophages in vitro and the influence of cocultures with tumour cells (monolayer, spheroids). These experiment s have shown that differentiation can be suppressed by tumour cells wi th three-dimensional growth. Theses findings are of interest for (a) a doptive immunotherapy and (b) the interpretation of tumour-infiltratin g macrophages. These tests are not suitable for in vitro monitoring of clinical immunotherapy.