INTRALESIONAL METHOTREXATE IN KERATOACANTHOMA OF THE NOSE

Keratoacanthomas are rapidly growing benign cutaneous neoplasms, usual ly occurring on sun-exposed areas of the body. Although many treatment modalities have been described, surgical excision is currently the tr eatment of choice for the majority of keratoacanthomas. Occasionally, however, the size and location of these lesions preclude complete exci sion without extensive reconstruction and/or scarring. Two such cases of large keratoacanthoma of the nose were treated successfully with in tralesional methotrexate. The rapid regression and very acceptable fin al cosmetic result suggest that intralesional methotrexate may play a beneficial role in the treatment of these difficult lesions and encour age further study of the benefits of this treatment modality.