EFFECT OF S-TRIAZINE COMPOUNDS ON TESTOSTERONE-METABOLISM IN THE RAT PROSTATE

The influence of s-triazine compounds (atrazine, prometryne and deethy latrazine) on testosterone conversion and 5 alpha-dihydrotestosterone- receptor complex formation was studied in vitro and in vivo in the rat prostate. A marked in vitro influence of atrazine and prometryne (fro m 0.465 to 1.392 mu mol) and their mixtures (in total concentration, 0 .928 mu mol) on 5 alpha-dihydrotestosterone formation was detected, 5 alpha-Dihydrotestosterone-specific receptor complex formation was inhi bited in vitro by ca. 0.5 mu mol of atrazine or deethylatrazine and on ly in vivo by 6 mg of atrazine 100 g(-1) body wt. daily during 7 days in the prostate cytosol. The inhibition of the enzymic activities resp onsible for testosterone conversion and steroid hormone-receptor compl ex formation was non-competitive and reversible, and s-triazine compou nds act as antiandrogens.