PREPARATION AND BIOLOGICAL EVALUATION OF TECHNETIUM-99M-PHENYLETHYLAMINE COMPLEXES

Authors
VITALE AA CALVINO MA FERRARI CC STAHL AE POMILIO AB
Citation
Aa. Vitale et al., PREPARATION AND BIOLOGICAL EVALUATION OF TECHNETIUM-99M-PHENYLETHYLAMINE COMPLEXES, Journal of labelled compounds & radiopharmaceuticals, 36(6), 1995, pp. 509-519
Citations number
35
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
36
Issue
6
Year of publication
1995
Pages
509 - 519
Database
ISI
SICI code
0362-4803(1995)36:6<509:PABEOT>2.0.ZU;2-B
Abstract
Biological and chemical characteristics of Tc-99m-phenethylamines comp lexes are presented. 2-(4,5-Dimethoxy-2-nitrophenyl)ethylamine, 2-(3,4 -dimethoxyphenyl)ethylamine and 2-(2-amino-4,5-dimethoxyphenyl)ethylam ine were used as ligands. A preliminary evaluation of these Tc-99m-com plexes as dopamine receptor radioligands was also performed. Net charg es at each atom were also calculated by a semiempirical ZINDO/1 method for comparison of free ligands' parameters with those of the respecti ve technetium-complexes.