MYOCARDIAL-ISCHEMIA INDUCED BY TOPICAL USE OF 5-FLUOROURACIL

Authors
ROZENMAN Y GUREWICH J GOTSMAN MS
Citation
Y. Rozenman et al., MYOCARDIAL-ISCHEMIA INDUCED BY TOPICAL USE OF 5-FLUOROURACIL, International journal of cardiology, 49(3), 1995, pp. 282-283
Citations number
8
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
International journal of cardiology → ACNP
ISSN journal
01675273
Volume
49
Issue
3
Year of publication
1995
Pages
282 - 283
Database
ISI
SICI code
0167-5273(1995)49:3<282:MIBTUO>2.0.ZU;2-L
Abstract
An 85-year-old woman, with known stable angina pectoris, was prescribe d 5-fluorouracil cream to treat a small basal cell carcinoma on the fo rehead. Half an hour after application the patient developed her typic al ischemic pain which persisted for 2 hours. Rechallenge, during hosp italization, resulted in recurrence of symptoms that were effectively controlled with sublingual isosorbide dinitrate. Prophylactic therapy with nitroglycerin patch enabled further use of the 5-fluorouracil cre am for the next month.