Gallstones are occasionally spilled into the peritoneal cavity during
open and laparoscopic cholecystectomy. Using the rat model, we investi
gated the long term effect of such retained intraperitoneal gallstones
. During a follow-up period of one year, no systemic deleterious outco
me could be attributed to the presence of the implanted gallstones exc
ept for mild local effects. Based on the rat model we conclude that re
asonable effort should be made in order to retrieve an escaped gallsto
ne, but there is no justification whatsoever for a conversion of the l
aparoscopic procedure to an open laparotomy only for the purpose of re
trieving a lost stone.