INTESTINAL COINFECTION WITH NUMEROUS GIARDIA TROPHOZOITES AND VIBRIO-CHOLERAE IN HOSPITALIZED CHILDREN WITH WATERY DIARRHEA

During the recent cholera epidemic which affected Peru and other Latin American countries, fresh stool samples of 100 hospitalized children were assessed February through April 1991. The children had been admit ted because of profuse watery diarrhea. The microbiologic study of wet mount preparations showed curved bacteria suspicious for cholera agen t and confirmed afterward to be Vibrio cholerae 01 serotype Inaba. In 30% of such cases, besides the curved bacteria, a strikingly large num ber of trophozoites of Giardia intestinalis were observed. The same sa mples studied by permanent stains confirmed the presence of Giardia tr ophozoites. To our knowledge, the association of Giardia with serious epidemic cholera infection has not been previously described. All pati ents were admitted because of severe dehydration requiring intravenous fluid replacement, which might suggest a synergistic role for the abo ve-noted coinfection. Adequately designed case-control studies are nee ded to ascertain the frequency and the pathophysiologic and clinical s ignificance of such an unusual association.