In Vanuatu malaria is a major killer, especially of young children. As
most deaths occur outside the hospital it is very important to have s
imple, clear guidelines on the management of patients with suspected m
alaria for the primary health care workers who treat the majority of c
ases. Despite the encouragement of early treatment, malaria was the ma
jor cause of death in children after the neonatal period in 1988, Duri
ng 1989 and 1990 the treatment of malaria in Vanuatu was reviewed with
the aim of trying to reduce the morbidity and mortality from the dise
ase. New guidelines were included in the Vanuatu Health Workers' Manua
l, issued to all nurses, nurse practitioners and doctors in 1991. The
major changes were the introduction of immediate slide microscopy, the
use of a combination of chloroquine and sulphadoxine-pyrimethamine fo
r Plasmodium falciparum malaria and for children under 5 years and pre
gnant women, the discontinuation of single-dose primaquine (previously
given as a gametocytocidal agent), and the use of a loading dose of q
uinine. The constraints of the previous guidelines, the rationale for
the changes and the expected improvements resulting from using the new
treatments are discussed.