PHENAMIDE, A FUNGICIDAL METABOLITE FROM STREPTOMYCES-ALBOSPINUS A19301 - TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

A new derivative of phenylalanine, phenamide, was discovered from the fermentation broth of an actinomycete identified as a member of the St reptomyces albospinus cluster. Phenamide was purified using successive C18 reverse phase and cation exchange chromatography. Its structure w as determined by spectroscopic and chemical methods. Its molecular for mula, C14H20N2O3, was determined by HRFAB-MS. Phenamide showed activit y against Septoria nodorum, the causal agent of wheat glume blotch.