S. Zijlstra et al., N-[F-18]-FLUOROALKYLATION OF NORAPORPHINES - MICROWAVE VERSUS THERMAL-TREATMENT, European journal of morphology, 33(2), 1995, pp. 154-157
A comparable study of microwave versus thermal heating is described fo
r the N-[F-18]-fluoroalkylation of noraporphines. As compared to therm
al treatment, different products were obtained during microwave treatm
ent. Thermal treatment resulted in the loss of the protection of the c
atechol functionality of the noraporphines (O-deacylation), whereas du
ring microwave treatment N-[F-18]-fluoroalkylation was observed. The r
esults described in this report might suggest that the influence of mi
crowaves on chemical transformations is not exclusively thermal.