PROTEIN PROFILING OF THE MYOCARDIUM EXPOSED TO PRESSURE-OVERLOAD FROMBIRTH

Authors
CERNOHORSKY J PELOUCH V MILEROVA M OSTADAL B
Citation
J. Cernohorsky et al., PROTEIN PROFILING OF THE MYOCARDIUM EXPOSED TO PRESSURE-OVERLOAD FROMBIRTH, Physiological Research, 44(2), 1995, pp. 139-142
Citations number
12
Categorie Soggetti
Physiology
Journal title
Physiological Research → ACNP
ISSN journal
08628408
Volume
44
Issue
2
Year of publication
1995
Pages
139 - 142
Database
ISI
SICI code
0862-8408(1995)44:2<139:PPOTME>2.0.ZU;2-#
Abstract
Aortic banding induced in 2-day-old (A2) and 6-day-old (A6) male rats increased the left ventricular (LV) weight after 60 days; right ventri cular (RV) enlargement occurred in the A2 group only. The concentratio n of collagenous proteins in the LV was elevated in both experimental groups (more in the A2 rats) at the expenses of sarcoplasmic proteins. Aortic banding also affected the proportion of collagen types (lower collagen I, higher collagen III, V) and myosin light chains (higher LC 1/LC2) in the LV. Similar changes of proteins in the RV were less pron ounced.