Zj. Lesnikowski et Rf. Schinazi, BORON NEUTRON-CAPTURE THERAPY OF CANCERS - NUCLEIC BASES, NUCLEOSIDES, AND OLIGONUCLEOTIDES AS POTENTIAL BORON CARRIERS, Polish Journal of Chemistry, 69(6), 1995, pp. 827-840
Basic principle and practice of boron neutron capture therapy of cance
rs (BNCT) is described. Boron modified oligonucleotides and their comp
onents, nucleosides and nucleic bases, and in particular derivatives c
ontaining boron cluster ligands are discussed. Boron bearing oligonucl
eotides are potentially tumor specific, boron rich carrier molecules f
or BNCT. They may find application as antisense agents for antisense o
ligonucleotide thera py (AOT) of cancers a nd viral infections, and as
molecular probes for diagnosis of genetic diseases.