BIOCATALYTIC RESOLUTION OF 2-METHYL-2-(ARYL)ALKYLOXIRANES USING NOVELBACTERIAL EPOXIDE HYDROLASES

Authors
OSPRIAN I KROUTIL W MISCHITZ M FABER K
Citation
I. Osprian et al., BIOCATALYTIC RESOLUTION OF 2-METHYL-2-(ARYL)ALKYLOXIRANES USING NOVELBACTERIAL EPOXIDE HYDROLASES, Tetrahedron : asymmetry, 8(1), 1997, pp. 65-71
Citations number
39
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
1
Year of publication
1997
Pages
65 - 71
Database
ISI
SICI code
0957-4166(1997)8:1<65:BRO2UN>2.0.ZU;2-C
Abstract
Biocatalytic resolution of alkyl- and (arylalkyl)-oxiranes was accompl ished by employing the epoxide hydrolase activity of lyophilized whole cells of seven bacterial strains belonging to the genera Rhodococcus, Mycobacterium and Nocardia. Whereas no suitable biocatalyst was found for 1-octene oxide, excellent selectivities were obtained with 2-meth yl-2-substituted epoxides bearing an alkyl- or (aryl)alkyl side chain. (C) 1997, Elsevier Science Ltd. All rights reserved.