LIPASE-CATALYZED RESOLUTION OF (R)-1-TRIMETHYLSILYL-1-ALKYN-3-OLS AND(S)-1-TRIMETHYLSILYL-1-ALKYN-3-OLS - USEFUL INTERMEDIATES FOR THE SYNTHESIS OF OPTICALLY-ACTIVE GAMMA-LACTONES

Authors
ALLEVI P CIUFFREDA P ANASTASIA M
Citation
P. Allevi et al., LIPASE-CATALYZED RESOLUTION OF (R)-1-TRIMETHYLSILYL-1-ALKYN-3-OLS AND(S)-1-TRIMETHYLSILYL-1-ALKYN-3-OLS - USEFUL INTERMEDIATES FOR THE SYNTHESIS OF OPTICALLY-ACTIVE GAMMA-LACTONES, Tetrahedron : asymmetry, 8(1), 1997, pp. 93-99
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
1
Year of publication
1997
Pages
93 - 99
Database
ISI
SICI code
0957-4166(1997)8:1<93:LRO(A>2.0.ZU;2-Z
Abstract
Various (R)- and (S)-1-trimethylsilyl-1-alkyn-3-ols, chiral building u nits useful for the synthesis of biologically active compounds, have b een efficiently resolved by enantioselective acetylation mediated by i mmobilized lipase PS. The resolution is applied to the synthesis of (R )- and (S)-5-octyl-2-(5H)-furanones. (C) 1997, Elsevier Science Ltd. A ll rights reserved.