ESTERASE COMPARISON IN NEUROBLASTOMA-CELLS OF HUMAN AND RODENT ORIGIN

1. Activities of acetylcholinesterase (AChE), neuropathy target estera se (NTE), and carboxylesterase (CbxE) were compared in neuroblastoma c ells of human origin (SH-SY5Y) and murine origin (NB41A3). 2. Mouse ne uroblastoma cells had lower specific activities of NTE and CbxE than d id human neuroblastoma cells; specific activities in the murine cells correlated with specific activities in mouse brain. 3. AChE activities in mouse and human neuroblastoma cells were considerably lower than A ChE activities in mouse or hen brain. 4. Inhibition of esterases did n ot demonstrate interspecies differences for 12 of the 17 anti-esterase compounds tested with human and mouse neuroblastoma cells.